Amphioxus immunity : tracing the origins of human immunity by An-Long Xu PDF

By An-Long Xu

ISBN-10: 0128096470

ISBN-13: 9780128096475

ISBN-10: 0128499036

ISBN-13: 9780128499030

Amphioxus Immunity: Tracing the beginning of Human Immunity covers a outstanding diversity of knowledge approximately Amphioxus and its evolutionary context. This compilation of what's presently identified approximately Amphioxus, with a pointy specialise in its immune procedure, contains thirteen issues, such as:

  • Amphioxus as a version for figuring out the evolution of vertebrates
  • basic wisdom of immunology
  • immune organs and cells of amphioxus
  • a genomic and transcriptomic view of the Amphioxus immunity
  • pattern acceptance approach in Amphioxus
  • transcription components in Amphioxus
  • the supplement procedure of Amphioxus
  • the oxidative burst approach in Amphioxus
  • immune effectors in Amphioxus
  • lipid signaling of immune reaction in Amphioxus
  • apoptosis in amphioxus; primitive adaptive immune method of Amphioxus
  • and destiny study directions

This important reference booklet is loaded with info that may be invaluable for someone who needs to benefit extra concerning the foundation of vertebrates and adaptive immunity.

  • Provides new proof at the foundation of the adaptive immune approach, the evolution of innate immunity, and evolution-stage particular immune safeguard mechanisms
  • Not in simple terms offers the cells and molecules excited about the adaptive immune reaction in Amphioxus, but additionally characterizes the origination and evolution of the gene households and pathways desirous about innate immunity
  • Includes a lot pioneering paintings, from the molecular, genomic, and mobile to the person level

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Additional resources for Amphioxus immunity : tracing the origins of human immunity

Sample text

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell 122, 669–682. , 2005. Regulation of plasma-cell development. Nat. Rev. Immunol. 5, 230– 242. , 2009. CD36, a scavenger receptor involved in immunity, metabolism, angiogenesis, and behavior. Sci. Signal. 2, re3. , 2007. Activation of the beta interferon promoter by unnatural Sendai virus infection requires RIG-I and is inhibited by viral C proteins. Virol. 81, 12227–12237.

227, 54–65. , 2005. The C-type lectin-like domain superfamily. FEBS J. 272, 6179–6217. 1 INTRODUCTION Amphioxus is considered as a living invertebrate most closely related to vertebrates. Together with vertebrates and urochordates, amphioxus descended from a common ancestor that lived more than 500 million years ago (Koop and Holland, 2008). 7). They are relatively sedentary filter feeders on small organisms such as diatoms and organic particles. 8). Water taken in with food exits from the gill slits into the atrial cavity and then returns to the environment through a ventral atriopore.

2011. RIG-I RNA helicase activation of IRF3 transcription factor is negatively regulated by caspase-8-mediated cleavage of the RIP1 protein. Immunity 34, 340–351. , 2014. Pattern recognition and signaling mechanisms of RIG-I and MDA5. Front. Immunol. 5, 342. The sterile inflammatory response. Annu. Rev. Immunol. 28, 321–342. , 2005. Molecular genetics of T cell development. Annu. Rev. Immunol. 23, 601–649. , 2006. Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif.

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Amphioxus immunity : tracing the origins of human immunity by An-Long Xu

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